Effect of Combined Treatment of Modern and Herbal Supplement in the Management of Letrozole Induced Polycystic Ovary Syndrome

Polycystic Ovary Syndrome (PCOS) has a prevalence of developing obesity, Type II diabetes, and cardiovascular disorder. These metabolic disorders and PCOS pathogenesis involve Oxidative Stress (OS) and low-grade inflammation. There are many modern drugs available for the treatment of PCOS, such as Clomifene Citrate (CC) but these drugs not work with abovementioned etiologies of PCOS. Hence, treatment of PCOS required an herbal supplement to manage the OS and low-grade inflammation. Exudates of Commiphora Mukul (CM) having anti-inflammatory and antioxidant properties was used as an herbal supplement. The purpose of the study was to evaluate the protective effect of CM alone and in combination with CC in Letrozole (LTZ) induced PCOS rats. Letrozole induced PCOS rats showed a significant increase in testosterone level, High Sensitive C-Reactive Protein (HSCRP), interleukin6 (IL-6), Lipid Peroxidation (LPO), significant decrease in the level of Superoxide Dismutase (SOD) and catalase. Combined treatment of CM and CC significantly decreases testosterone, HSCRP, IL-6, LPO and increases SOD and catalase. The combined treatment also induces ovulation and decreases number of cystic follicles. This study indicates the supplement of CM with CC have higher therapeutic value as compared to modern drug CC.